Last, but not least, we want to mention a pretty big (but subjectively evaluated), Avene (the French pharmacy brand famous for its Retinal products) sponsored study that examined the tolerability and efficacy of a 0.1 Retinal + 6% glycolic acid product in the treatment of acne. They found that " the natural retinoids ROL and RAL do have a good tolerance profile, in contrast with the irritating potential of RA", meaning retinal is an awesome alternative if you have irritation and flaking issues with prescription products, such as Retin-A. The good tolerability of retinal was also confirmed by another study that compared retinol (ROL), retinal (RAL) and retinoic acid (RA). (Interestingly, in both groups, the results were less significant at week 44, so it might be a good idea to have a retinoid break from time to time?) Also, our guy, Retinal was much better tolerated than retinoic acid known for its harshness. They concluded that " at week 18, a significant reduction of the wrinkle and roughness features was observed with both retinaldehyde and retinoic acid." and the difference between the two was not statistically significant. This sounds good, but how does Retinal compare to retinoic acid? Good question! We found a study (a pretty good one with 125 patients) that compared 0.05% retinal with 0.05% retinoic acid (and vehicle). In a nutshell, it is everything you expect from an anti-aging superstar such as decreased wrinkles, smoother, firmer and more elastic skin. Once retinal is converted, it becomes retinoic acid and does the same things we detailed in our tretinoin description. If we go with our royal family analogy, Retinal is Prince William, directly next in line to the throne. ![]() So where does our current molecule, Retinal, aka Retinaldehyde fit into the family (btw, here is a nice visual family tree about who is who)? Remember that retinol needed two conversion steps to become retinoic acid? Yes, you are right, Retinal is the intermediate step between retinoic acid and retinol, meaning it needs only one conversion step to become active in the skin. The conversion means retinol is both less effective and less harsh on the skin. Retinol is like a grandkid, it has to be converted (through two steps) in the skin to become retinoic acid. The TL DR version is that retinoids are the royal family of skincare with tretinoin being the king, the only FDA-approved ingredient to treat the signs of photoaging. If you are reading here, we are pretty sure the words retinoids and retinol ring a bell, but if not, you are seriously missing out, please click here immediately to catch up. Lonicera Japonica (Honeysuckle) Flower Extract Lonicera Caprifolium (Honeysuckle) Flower Extract Rosmarinus Officinalis (Rosemary) Leaf Oil Melaleuca Alternifolia (Tea Tree) Leaf Oil Epilobium Angustifolium Flower/Leaf/Stem ExtractĬhamomilla Recutita (Matricaria) Flower Extract
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